Description

Cyclopropanecarboxylic Acid, 2-Fluoro-, 1,1-Dimethylethyl Ester, (1R,2R)-Rel- is a high-purity, stereochemically defined fluorinated cyclopropane derivative. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise three-dimensional architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in CNS and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and fluorinated cyclopropane scaffold.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to construct complex, biologically active molecules.
• Agrochemical Research: Potential intermediate in the development of new generation pesticides and herbicides with improved efficacy.
• Material Science: Investigated for the synthesis of specialty polymers and liquid crystals where the rigid cyclopropane ring and fluorine atom impart unique properties.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-, 1,1-Dimethylethyl Ester, (1R,2R)-Rel-
CAS No.	152237-14-4
Molecular Formula	C9H15FO2
Molecular Weight	174.21 g/mol
Synonyms	(1R,2R)-rel-2-Fluorocyclopropanecarboxylic acid tert-butyl ester; tert-Butyl (1R,2R)-rel-2-fluorocyclopropanecarboxylate; (1R,2R)-rel-2-Fluorocyclopropanecarboxylic acid 1,1-dimethylethyl ester; 2-Fluorocyclopropanecarboxylic acid tert-butyl ester, (1R,2R)-rel-; (rel)-(1R,2R)-tert-Butyl 2-fluorocyclopropanecarboxylate; Fluorinated cyclopropane tert-butyl ester; Chiral fluorocyclopropane building block
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-, 1,1-Dimethylethyl Ester, (1R,2R)-Rel- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.