Description

Cefotaxime CAS NO 152186-43-1 is a broad-spectrum third-generation cephalosporin antibiotic belonging to the β-lactam class. It is valued for its potent activity against a wide range of Gram-positive and Gram-negative bacteria, including many β-lactamase-producing strains. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotics used in hospital and clinical settings to treat serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for intravenous or intramuscular administration.
• Hospital Infection Treatment: Used in the management of severe infections such as meningitis, septicemia, pneumonia, and complicated urinary tract infections.
• Surgical Prophylaxis: Employed to prevent post-operative infections in various surgical procedures.
• Gynecological and Obstetric Infections: Treatment of pelvic inflammatory disease and other serious infections in this field.
• Pediatric and Neonatal Care: Formulated for use in treating serious bacterial infections in children and neonates, where its safety profile is well-established.
• Research & Development: Serves as a reference standard and key intermediate in pharmaceutical R&D for new antibiotic formulations and combination therapies.

Basic Information

Item	Details
Product Name	Cefotaxime
CAS No.	152186-43-1
Molecular Formula	C16H17N5O7S2
Molecular Weight	455.47 g/mol
Synonyms	Cefotaxime Sodium; (6R,7R)-3-(Acetoxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Claforan; Cefotax; Zariviz; Cephotaxime; HR-756
EINECS	Contact for details

Quality Control

Our Cefotaxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
pH (1% Solution)	4.5 - 6.5
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.