Description

Uroguanylin CAS NO 152175-68-3 is a synthetic peptide hormone that plays a critical role in regulating intestinal fluid and electrolyte homeostasis. This compound is of significant interest for its potential as a research tool and therapeutic agent targeting guanylate cyclase-C (GC-C) receptors. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on gastrointestinal physiology, secretory diarrhea, and metabolic disorders.

Application

• Pharmaceutical Research & Development: As a key reference standard and active agent in studies of guanylate cyclase-C (GC-C) receptor signaling pathways.
• Gastrointestinal Physiology Studies: For investigating intestinal fluid secretion, electrolyte transport, and mucosal barrier function in preclinical models.
• Therapeutic Target Exploration: In the development of novel treatments for conditions like chronic constipation, irritable bowel syndrome (IBS), and secretory diarrheas.
• Biochemical Assay Development: Used as a critical component in cell-based assays and binding studies to screen for GC-C receptor agonists or antagonists.
• Metabolic Disorder Research: For exploring the role of uroguanylin in appetite regulation, energy balance, and potential links to obesity.
• Academic & Institutional Research: Serves as a vital reagent for basic science research in endocrinology and peptide biology.

Basic Information

Product Name	Uroguanylin
CAS No.	152175-68-3
Molecular Formula	C106H168N34O33S4
Molecular Weight	2459.9 g/mol
Synonyms	Uroguanylin (human); Guanylin urointestinal peptide; UGN; hUGN; Guanylate cyclase activator 1B; Preproguanylin; Uroguanylin Peptide; 152175-68-3; Uroguanylin-18; hUroguanylin
EINECS	Contact for details

Quality Control

Our Uroguanylin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to GMP-grade standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.