Description

Dexamethasone B-D-Glucuronide is a crucial conjugated metabolite of the potent synthetic glucocorticoid, dexamethasone. This compound is essential for researchers and manufacturers involved in metabolic profiling, pharmacokinetic studies, and the development of analytical standards. It serves as a vital reference material for laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors, enabling precise quantification and understanding of dexamethasone metabolism and clearance pathways.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of dexamethasone and its metabolites in drug development and quality control.
• Metabolite Identification & Profiling: Critical for in vitro and in vivo studies to map the metabolic pathways and biotransformation of dexamethasone.
• Clinical Research & Diagnostics: Used in the development and validation of diagnostic assays, including LC-MS/MS methods, to monitor dexamethasone levels in biological matrices for therapeutic drug monitoring (TDM).
• Biomarker Research: Investigation of glucocorticoid-related physiological and pathological processes by studying its conjugated metabolite levels.
• Enzyme Activity Studies: Serves as a specific substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in phase II drug metabolism.
• Regulatory Compliance Testing: Essential for laboratories requiring high-purity standards to comply with FDA, EMA, and ICH guidelines for impurity profiling and method validation.

Basic Information

Product Name	Dexamethasone B-D-Glucuronide
CAS No.	152154-28-4
Molecular Formula	C27H37FO12
Molecular Weight	572.58 g/mol
Synonyms	Dexamethasone β-D-Glucuronide; Dexamethasone Glucuronide; Dexamethasone 21-Glucuronide; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-β-D-glucopyranosiduronic acid; Dexamethasone 21-(β-D-Glucopyranosiduronate); Dexamethasone Glucuronide Conjugate
EINECS	Contact for details

Quality Control

Our Dexamethasone B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.