Description

(-)-Emtricitabine o-β-D-Glucuronide is a crucial metabolite and reference standard of the antiviral drug emtricitabine. This compound is essential for advanced pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development and quality control of antiviral therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of emtricitabine and its metabolites in drug substances and products.
• Metabolite Identification & Pharmacokinetic Studies: Critical for in vitro and in vivo studies to understand the metabolic pathways, distribution, and excretion profiles of emtricitabine.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for the detection of emtricitabine-glucuronide in biological matrices (e.g., plasma, urine).
• Drug Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of emtricitabine-based drug formulations.
• Clinical Research: Employed in clinical trials to monitor drug metabolism and establish dose-response relationships for antiviral therapies.

Basic Information

Product Name	(-)-Emtricitabine o-β-D-Glucuronide
CAS No.	152128-78-4
Molecular Formula	C14H19FN3O7S
Molecular Weight	392.38 g/mol
Synonyms	Emtricitabine Glucuronide; Emtricitabine O-β-D-Glucuronide; FTC-Glucuronide; 5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytidine β-D-Glucopyranosiduronic Acid; 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone β-D-Glucopyranosiduronic Acid; BW 1592U89 Glucuronide; Coviracil Glucuronide
EINECS	Contact for details

Quality Control

Our (-)-Emtricitabine o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.