Description

Desferrioxamine B-Succinyl-Phenylalanine(1)-Octreotide is a sophisticated synthetic peptide conjugate designed for targeted therapeutic and diagnostic applications. This compound matters for its unique ability to combine the iron-chelating properties of desferrioxamine with the tumor-targeting specificity of the octreotide peptide. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on advanced oncology treatments, radiopharmaceuticals, and molecular imaging agents. The precise molecular architecture enables site-specific delivery for enhanced efficacy and reduced systemic side effects.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling with diagnostic (e.g., Gallium-68) or therapeutic (e.g., Lutetium-177) radionuclides for targeted cancer imaging and therapy.
• Oncology Research: Used in the development of targeted drug delivery systems for cancers expressing somatostatin receptors (SSTRs), such as neuroendocrine tumors.
• Molecular Imaging Probes: Serves as a key component in constructing probes for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Therapeutic Conjugate Development: Investigated for creating conjugates that deliver cytotoxic agents or chelated metals specifically to tumor sites.
• Biochemical Research: Utilized as a tool compound in studies of receptor-mediated endocytosis, iron metabolism in specific cell types, and peptide-drug conjugate stability.
• Preclinical Studies: Employed in animal models to evaluate biodistribution, pharmacokinetics, and therapeutic efficacy of novel targeted agents.

Basic Information

Product Name	Desferrioxamine B-Succinyl-Phenylalanine(1)-Octreotide
CAS No.	151956-24-0
Molecular Formula	C82H122N20O23S2
Molecular Weight	1795.1 g/mol
Synonyms	DFO-SP1-OCT; DFO-succ-Phe(1)-Octreotide; Desferrioxamine B linked to Octreotide via Succinyl-Phenylalanine; DFO-Octreotide Conjugate; DOTA-free Octreotide Analog; DFO-TOC precursor; Somatostatin receptor-targeting DFO conjugate; Nα-(5-Acetamido-1-[4-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(1S)-1-hydroxy-3-[(5-{N-[5-(N-hydroxycarbamimidoyl)-1-{N-[5-(N-hydroxycarbamimidoyl)pentanoyl]pentanamido}pentyl]carbamimidoyl}pentanoyl)amino]propyl]pentyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentyl]carbamoyl)pentyl]-2,5-dioxopyrrolidin-3-yl)carbamic acid
EINECS	Contact for details

Quality Control

Our Desferrioxamine B-Succinyl-Phenylalanine(1)-Octreotide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, and related substance profiles are available upon request. We support development with custom purity grades and analytical method support.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular weight
Purity (HPLC)	≥95.0% (Area Percent)
Single Largest Impurity (HPLC)	≤2.0%
Total Impurities (HPLC)	≤5.0%
Peptide Content (Amino Acid Analysis)	≥80.0%
Water Content (KF)	≤5.0%
Acetate Content (HPLC/IC)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.