Description

2-Fluoro-3-(trifluoromethyl)anisole is a high-value fluorinated aromatic building block, distinguished by its unique combination of fluorine and methoxy substituents. This compound is essential for introducing specific steric and electronic properties into advanced molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to incorporate fluorine into polymer backbones, improving chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Organic Synthesis Building Block: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution in complex molecule construction.
• Chemical Research & Development: Critical for academic and industrial R&D exploring new fluorination methodologies and the properties of fluorinated arenes.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)anisole
CAS No.	151868-17-6
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	1-Fluoro-2-methoxy-3-(trifluoromethyl)benzene; 2-Fluoro-3-(trifluoromethyl)phenyl methyl ether; 3-Trifluoromethyl-2-fluoroanisole; Benzene, 1-fluoro-2-methoxy-3-(trifluoromethyl)-; 2-Methoxy-6-fluoro-α,α,α-trifluorotoluene; 2-Fluoro-α,α,α-trifluoro-3-methoxytoluene; 3-Methoxy-2-fluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)anisole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.35 g/cm³
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.