Description

Big Endothelin-2 (Human) Ammonium is a high-purity, synthetic peptide corresponding to the biologically active form of human endothelin-2. This compound is a critical research tool for investigating the endothelin system, which plays a pivotal role in cardiovascular regulation, cell proliferation, and various disease pathways. It is essential for scientists and developers in pharmaceutical research, biochemical assay development, and academic studies focused on vasoconstriction, hypertension, and cancer biology.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of endothelin receptor (ETB) binding, signaling, and physiological effects.
• Assay Development: Serves as a critical component in the development and validation of ELISA, RIA, and other immunoassays for endothelin detection.
• Drug Discovery: Acts as a target molecule for screening and evaluating potential endothelin receptor antagonists in cardiovascular and oncology therapeutic programs.
• Cell Culture & Physiology: Applied in vitro to study its effects on vascular smooth muscle contraction, cell growth, and hormone secretion.
• Academic & Institutional Studies: Fundamental reagent for investigating the role of endothelin-2 in disease models, including pulmonary hypertension, heart failure, and tumor progression.
• Quality Control: Employed as a system suitability standard in the pharmaceutical analysis of endothelin-related products.

Basic Information

Product Name	Big Endothelin-2 (Human) Ammonium
CAS No.	151853-67-7
Molecular Formula	C121H183N35O40S4 • xNH3
Molecular Weight	~2690.1 g/mol (free acid)
Synonyms	Endothelin-2 (1-38), human; ET-2; ET2; Big ET-2; Preproendothelin-2 (93-130); [Ala1,3,11,15]-Endothelin-2 (Human); Big Endothelin-2; Endothelin-2 Precursor
EINECS	Contact for details

Quality Control

Our Big Endothelin-2 (Human) Ammonium is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and endotoxin testing. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.