Description

Rel-10-[(1R,2S)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]-1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid is a high-purity, functionalized macrocyclic chelator, a derivative of the widely used DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). This compound is specifically engineered for the stable complexation of diagnostic and therapeutic radiometals, such as Gallium-68, Lutetium-177, and Yttrium-90. It is an essential intermediate for research institutions and pharmaceutical companies developing next-generation radiopharmaceuticals for targeted cancer imaging (PET/SPECT) and radionuclide therapy.

Application

• Radiopharmaceutical Precursor: Key building block for synthesizing targeted diagnostic and therapeutic agents.
• PET Imaging Probes: Chelator for Gallium-68 (68Ga) in positron emission tomography (PET) tracers.
• Therapeutic Radiopharmaceuticals: Bifunctional chelator for β-emitting isotopes like Lutetium-177 (177Lu) and Yttrium-90 (90Y) used in targeted radionuclide therapy (TRT).
• Research Chemical: Used in academic and industrial R&D for studying metal-ligand kinetics, stability constants, and novel conjugation chemistry.
• Contrast Agent Development: Potential use in the development of gadolinium-based MRI contrast agents with modified pharmacokinetics.
• Peptide & Antibody Conjugation: Functionalized backbone for site-specific conjugation to targeting vectors like peptides, antibodies, or small molecules.

Basic Information

Product Name	Rel-10-[(1R,2S)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]-1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid
CAS No.	151852-61-8
Molecular Formula	C19H33N4O9
Molecular Weight	461.49 g/mol
Synonyms	DOTAGA-(R)-isothiocyanate precursor; (R)-DOTAGA tris(t-butyl ester); 1,4,7-Tris(carboxymethyl)-10-[(1R,2S)-1,2,3-trihydroxypropyl]-1,4,7,10-tetraazacyclododecane; Rel-10-[(1R,2S)-2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid; DOTAGA derivative; Bifunctional DOTA chelator; Macrocyclic triacetic acid derivative
EINECS	Contact for details

Quality Control

Our Rel-10-[(1R,2S)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]-1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.