Description

Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt CAS NO 151837-09-1 is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed as a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). This Rp-isomer is a crucial pharmacological tool for studying intracellular signal transduction pathways, offering superior stability against phosphodiesterase hydrolysis compared to its natural counterpart. It is essential for researchers and developers in pharmaceutical discovery, biochemical research, and cell biology, enabling precise manipulation and investigation of PKA-mediated processes.

Application

• Biochemical Research: As a selective PKA inhibitor to elucidate the role of cAMP in cellular signaling cascades.
• Pharmaceutical Development: Used in high-throughput screening and target validation for therapies related to heart disease, neurological disorders, and metabolic conditions.
• Cell Biology Studies: Investigating the effects of PKA inhibition on cell proliferation, differentiation, and gene expression.
• Enzymology: A standard reagent for in vitro kinase assays to study enzyme kinetics and inhibitor potency.
• Neuroscience Research: Probing cAMP/PKA pathways involved in synaptic plasticity, memory, and neurotransmitter release.
• Cardiovascular Research: Studying PKA's role in cardiac muscle contraction and ion channel regulation.

Basic Information

Product Name	Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt
CAS No.	151837-09-1
Molecular Formula	C10H12N5O5PS · C6H15N
Molecular Weight	492.44 g/mol (Free acid: 345.26 g/mol)
Synonyms	Rp-cAMPS triethylammonium salt; Adenosine 3',5'-cyclic monophosphorothioate, Rp-isomer; Rp-Adenosine 3',5'-cyclic monophosphorothioate; cAMP-S, Rp-isomer; Rp-cAMPS; Protein Kinase A Inhibitor, Rp-isomer; (Rp)-Adenosine cyclic 3',5'-phosphorothioate; 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphorothioate, Rp-isomer (common research analog)
EINECS	Contact for details

Quality Control

Our Adenosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the product meets the high standards required for pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.