Description

Ethanone, 2-Chloro-1-(1-Fluorocyclopropyl)- (9Ci) is a specialized fluorinated ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the combined chloro and fluorocyclopropyl substituents, enabling the construction of complex molecular architectures. This high-purity intermediate is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and process development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, where the fluorocyclopropyl group can enhance biological activity and metabolic stability.
• Advanced Material Synthesis: Serves as a precursor for specialty polymers and liquid crystals, where its structural motifs can influence material properties.
• Fluorine Chemistry: An important reagent for introducing fluorinated cyclopropane rings into target molecules, a valuable modification in lead optimization.
• Cross-Coupling Reactions: The chloroacetyl moiety can act as an electrophile in various metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Process Chemistry: Employed in route scouting and scale-up studies for the efficient production of complex organic molecules.

Basic Information

Product Name	Ethanone, 2-Chloro-1-(1-Fluorocyclopropyl)- (9Ci)
CAS No.	151697-21-1
Molecular Formula	C5H6ClFO
Molecular Weight	136.55 g/mol
Synonyms	2-Chloro-1-(1-fluorocyclopropyl)ethanone; 1-(1-Fluorocyclopropyl)-2-chloroethanone; 2-Chloro-1-(1-fluorocyclopropyl)ethan-1-one; α-Chloro-1-fluorocyclopropyl methyl ketone; Chlorofluorocyclopropyl methyl ketone; 151697-21-1; Ethanone, 2-chloro-1-(1-fluorocyclopropyl)-
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-1-(1-Fluorocyclopropyl)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.