Description

n-Hydroxymexiletine Glucuronide is a key glucuronide metabolite of the antiarrhythmic agent mexiletine, representing a critical standard for pharmaceutical research and development. This compound is essential for conducting precise pharmacokinetic studies, metabolic profiling, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on cardiovascular drug metabolism and safety assessment.

Application

• Reference Standard for Bioanalysis: Serves as a certified standard for the quantification of mexiletine metabolites in biological matrices (plasma, urine) using LC-MS/MS and HPLC methods.
• Pharmacokinetic & Metabolism Studies: Used to investigate the metabolic pathways, clearance rates, and bioavailability of mexiletine in preclinical and clinical research.
• Drug Impurity Profiling: Employed as an impurity marker in the quality control of mexiletine active pharmaceutical ingredient (API) to ensure purity and compliance.
• Enzyme Reaction Studies: Acts as a substrate or product in studies characterizing UDP-glucuronosyltransferase (UGT) enzyme activity and kinetics.
• Toxicological Assessment: Facilitates safety evaluations by enabling the study of metabolite formation and its potential role in drug-induced toxicity.

Basic Information

Product Name	n-Hydroxymexiletine Glucuronide
CAS No.	151636-18-9
Molecular Formula	C17H27NO8
Molecular Weight	373.40 g/mol
Synonyms	1-(2,6-Dimethylphenoxy)-2-propanol Glucuronide; Mexiletine Hydroxy Metabolite Glucuronide; N-Hydroxymexiletine β-D-Glucuronide; 1-(2,6-Dimethylphenoxy)-2-propanone Oxime Glucuronide; 2,6-Dimethylphenoxypropanone Oxime Glucuronide
EINECS	Contact for details

Quality Control

Every batch of n-Hydroxymexiletine Glucuronide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥95.0%
Assay	≥97.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.