Description

Growth Factor Receptor-Bound Protein 10 is a key signaling adaptor protein involved in the regulation of cellular growth, differentiation, and survival pathways. Its precise biochemical function makes it a critical reagent for advanced life science research and drug discovery programs targeting receptor tyrosine kinase signaling. This high-purity protein is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and molecular diagnostics who require reliable, well-characterized biological components.

Application

• Biochemical Research: Used as a purified protein standard or reagent in studies of intracellular signaling cascades, particularly those involving growth factor receptors like EGFR and insulin receptor substrates.
• Drug Discovery Screening: Serves as a target protein in high-throughput screening (HTS) assays to identify novel inhibitors or modulators of Grb10-mediated protein-protein interactions.
• Enzyme Kinetics Studies: Employed in in vitro assays to investigate phosphorylation dynamics and the kinetics of interactions with SH2 and other protein domains.
• Diagnostic Development: Utilized in the development of immunoassays (e.g., ELISA) and other detection methods for research into metabolic and growth disorders.
• Cell Signaling Pathway Analysis: A crucial component for reconstructing and analyzing specific signaling pathways in cell-free systems to understand mechanistic details.
• Antibody Production & Validation: Acts as a high-quality immunogen for generating specific monoclonal or polyclonal antibodies.

Basic Information

Product Name	Growth Factor Receptor-Bound Protein 10
CAS No.	151441-47-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Grb10; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; GRB10 adapter protein; MEG1; RSS; IRBP
EINECS	Contact for details

Quality Control

Our Growth Factor Receptor-Bound Protein 10 is produced and tested under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for purity, identity, and functional integrity using advanced analytical techniques. Certificates of Analysis (COA) detailing specific results for purity, endotoxin levels, and activity assays are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. Aliquot into working stocks upon first use to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at expected molecular weight
Purity (HPLC)	≥ 95%
Protein Content	Determined by UV absorbance
Biological Activity	Assessed by binding assay; details on COA
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.