Description

2,4,6-Trifluorobenzyl Bromide is a versatile and highly reactive organofluorine building block essential for advanced chemical synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which significantly influences the electronic properties and metabolic stability of target molecules. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex fluorinated intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and pesticides, where the trifluoromethylbenzyl moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving thermal stability and electronic performance.
• Cross-Coupling Reactions: Acts as an efficient electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating complex biaryl structures.
• Nucleophilic Substitution Scaffold: The reactive benzyl bromide group allows for facile functionalization with various nucleophiles, enabling rapid library synthesis for medicinal chemistry.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) tracers, leveraging its fluorinated aromatic structure.

Basic Information

Product Name	2,4,6-Trifluorobenzyl Bromide
CAS No.	151411-98-2
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	(2,4,6-Trifluorophenyl)methyl Bromide; α-Bromo-2,4,6-trifluorotoluene; 2,4,6-Trifluorobenzyl Bromide; 1-(Bromomethyl)-2,4,6-trifluorobenzene; 2,4,6-Trifluoro-α-bromotoluene; Benzene, 1-(bromomethyl)-2,4,6-trifluoro-; Bromomethyl-2,4,6-trifluorobenzene
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.