Description

2-Pyrrolidinecarbonitrile, 1-(Trifluoroacetyl)-, (S)- (9Ci) is a high-value, chiral building block featuring a pyrrolidine core functionalized with a nitrile and a trifluoroacetyl group. This compound matters for its role in the synthesis of complex, biologically active molecules, particularly in the pharmaceutical industry where its stereochemistry and functional groups are critical for drug efficacy. It is primarily needed by research chemists and process development scientists working on novel therapeutics, agrochemicals, and advanced materials. Our supply ensures high enantiomeric purity and batch-to-batch consistency for critical development and scale-up projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry enhances activity and reduces environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: The pyrrolidine scaffold is valuable for constructing peptidomimetics and protease inhibitors in medicinal chemistry programs.
• Material Science: Potential use in the development of specialty polymers and advanced organic materials with unique electronic or structural properties.
• Chemical Biology Probes: Employed as a building block for creating molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-Pyrrolidinecarbonitrile, 1-(Trifluoroacetyl)-, (S)- (9Ci)
CAS No.	151258-26-3
Molecular Formula	C7H7F3N2O
Molecular Weight	192.14 g/mol
Synonyms	(S)-1-(Trifluoroacetyl)-2-pyrrolidinecarbonitrile; (S)-2-Cyano-1-(trifluoroacetyl)pyrrolidine; 1-(Trifluoroacetyl)-L-prolinenitrile; L-Proline, 1-(trifluoroacetyl)-, nitrile; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carbonitrile; (S)-N-(Trifluoroacetyl)-2-cyanopyrrolidine; 2-Pyrrolidinecarbonitrile, 1-(trifluoroacetyl)-, (S)-; (S)-N-Trifluoroacetyl-2-cyanopyrrolidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with high enantiomeric excess (ee) and purity, critical for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are available upon request. Our quality system is designed to support cGMP and ISO guidelines for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.