Description

Morphine 3-(Tri-o-Acetyl-β-D-Glucuronide) Methyl Ester is a key synthetic intermediate and reference standard in pharmaceutical research and development. This compound is critical for the study of morphine metabolism, specifically the formation and analysis of its glucuronide conjugates. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in forensic toxicology, pharmacokinetic studies, and the development of advanced pain management therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quantifying morphine and its metabolites in biological matrices.
• Metabolite Research: Serves as a crucial intermediate for studying the Phase II glucuronidation pathway of morphine, aiding in understanding drug efficacy, toxicity, and individual metabolic variation.
• Forensic Toxicology: Essential for developing and validating confirmatory assays in workplace drug testing, post-mortem analysis, and clinical toxicology reports.
• Biochemical Synthesis: Acts as a protected precursor in the chemical synthesis of other morphine-derived compounds for pharmacological evaluation.
• Method Development & Validation: Employed by QC/QA laboratories to establish and verify the accuracy, precision, and specificity of new analytical procedures.

Basic Information

Product Name	Morphine 3-(Tri-o-Acetyl-β-D-Glucuronide) Methyl Ester
CAS No.	151250-15-6
Molecular Formula	C34H39NO14
Molecular Weight	685.67 g/mol
Synonyms	Morphine 3-Glucuronide Triacetate Methyl Ester; Methyl (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{[(4R,4aR,7S,7aR,12bS)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]oxy}oxane-2-carboxylate; Morphine-3-β-D-Glucuronide Triacetate Methyl Ester; Morphine 3-O-(Tri-O-acetyl-β-D-glucopyranuronate) Methyl Ester; M3G Triacetate Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Morphine 3-(Tri-o-Acetyl-β-D-Glucuronide) Methyl Ester is manufactured and handled under strict quality management protocols. Our products undergo rigorous identity, purity, and impurity profile testing using advanced chromatographic (HPLC, LC-MS) and spectroscopic (NMR, IR) techniques to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.