Description

Tfa-Cleu CAS NO 151159-24-9 is a specialized, high-purity protected amino acid derivative, specifically Nα-Trifluoroacetyl-L-leucine. This compound is a critical building block in the synthesis of complex peptides and pharmaceutical intermediates, offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid building block to introduce leucine residues while preventing unwanted side reactions.
• Bioconjugation and Labeling: Serves as a reagent for modifying peptides and proteins due to the reactivity of the trifluoroacetyl protecting group.
• Research & Development: Employed in academic and industrial R&D labs for studying peptide structure-activity relationships and developing new synthetic methodologies.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex organic molecules requiring specific chiral centers and protected functional groups.

Basic Information

Product Name	Tfa-Cleu
CAS No.	151159-24-9
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	Nα-Trifluoroacetyl-L-leucine; N-(Trifluoroacetyl)-L-leucine; TFA-L-Leucine; L-Leucine, N-[(trifluoroacetyl)-]; Trifluoroacetylleucine; (S)-2-(Trifluoroacetamido)-4-methylpentanoic acid; 151159-24-9; N-TFA-L-Leucine
EINECS	Contact for details

Quality Control

Our Tfa-Cleu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and chiral purity, and is accompanied by a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.