Description

1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarbonitrile is a high-value, synthetically versatile organic intermediate featuring a cyclobutane ring and a trifluoromethoxy-substituted aromatic system. This compound is prized for its unique structural motif, which imparts desirable physicochemical properties for advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing advanced functional materials used in display technologies and organic light-emitting diodes.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic systems in asymmetric synthesis.
• Polymer Modification: Acts as a monomer or cross-linking agent for developing specialty polymers with enhanced thermal and chemical resistance.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarbonitrile
CAS No.	151157-62-9
Molecular Formula	C12H10F3NO
Molecular Weight	241.21 g/mol
Synonyms	4-(Trifluoromethoxy)phenylcyclobutanecarbonitrile; 1-[4-(Trifluoromethoxy)phenyl]cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-[4-(trifluoromethoxy)phenyl]-; 1-(4-Trifluoromethoxyphenyl)cyclobutanecarbonitrile; 1-(4-(Trifluoromethoxy)phenyl)cyclobutanecarbonitrile; 4-(Trifluoromethoxy)benzenepropanenitrile, α,α-cyclobutyl-; α,α-Cyclobutyl-4-(trifluoromethoxy)benzenepropanenitrile
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Custom synthesis and purity grades (e.g., >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The material is moisture-sensitive; handle and store under inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.