Description

4-(Methylnitrosamino)-1-[3-(6-Hydroxypyridyl)-1-Butanone is a specialized nitrosamine compound of significant interest in advanced chemical research and development. This compound serves as a critical reference standard and synthetic intermediate for analytical and investigative purposes. It is primarily utilized by research institutions and pharmaceutical development laboratories focused on nitrosamine analysis, impurity profiling, and method validation studies.

Application

• Analytical Reference Standard: Used for the calibration and validation of analytical methods (e.g., HPLC, LC-MS) for nitrosamine detection and quantification.
• Pharmaceutical Impurity Profiling: Serves as a critical standard in identifying and quantifying nitrosamine drug substance-related impurities (NDSRIs) to ensure product safety and regulatory compliance.
• Metabolic and Toxicological Studies: Employed in research to understand the metabolic pathways, bioactivation, and toxicological profile of nitrosamine compounds.
• Chemical Synthesis Intermediate: Acts as a key building block in the synthesis of more complex molecules for research applications.
• Quality Control & Assurance: Essential for establishing and maintaining rigorous quality control protocols in pharmaceutical and chemical manufacturing where nitrosamine contamination is a concern.

Basic Information

Product Name	4-(Methylnitrosamino)-1-[3-(6-Hydroxypyridyl)-1-Butanone
CAS No.	151028-45-4
Molecular Formula	C10H13N3O2
Molecular Weight	207.23 g/mol
Synonyms	NNK; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; N-Nitrosonornicotine ketone; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridinyl)-1-butanone; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone; Tobacco-specific nitrosamine NNK; 1-(3-Pyridyl)-1-butanone 4-(methylnitrosamino)-
EINECS	Contact for details

Quality Control

Our 4-(Methylnitrosamino)-1-[3-(6-Hydroxypyridyl)-1-Butanone is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the exacting standards required for research and analytical applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.