Description

Bupropion-D9 Hydrochloride is a stable isotope-labeled analog of the antidepressant and smoking cessation aid bupropion, where nine hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative analytical methods in pharmaceutical research and development. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic studies, metabolite identification, and method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial internal standard for the precise quantification of bupropion and its metabolites in biological matrices (e.g., plasma, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Method Development and Validation: Used as a reference material to develop, optimize, and validate robust analytical methods in compliance with ICH, FDA, and EMA guidelines.
• Metabolite Profiling and Identification: Aids in the structural elucidation and quantification of bupropion metabolites, supporting drug safety and efficacy evaluations.
• Quality Control in Pharmaceutical Manufacturing: Acts as a certified reference material for in-process testing and final product release to ensure batch consistency and purity.
• Forensic and Doping Control Analysis: Employed in confirmatory testing for bupropion presence in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Bupropion-D9 Hydrochloride
CAS No.	150988-80-0
Molecular Formula	C13H9D9ClNO • HCl
Molecular Weight	310.27 g/mol
Synonyms	(±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-D9 Hydrochloride; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone-D9 Hydrochloride; Amfebutamone-D9 Hydrochloride; Wellbutrin-D9 Hydrochloride; Zyban-D9 Hydrochloride; BW A 444U-D9 Hydrochloride; NSC 329634-D9 Hydrochloride
EINECS	Contact for details

Quality Control

Our Bupropion-D9 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (typically ≥98 atom % D), chemical purity (≥98%), and all analytical results is provided with every shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.