Description

(R)-(+)-2,2'-Bis(Dicyclobutylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl CAS NO 150971-51-0 is a high-purity, chiral bisphosphine ligand designed for asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries seeking to develop efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the catalytic production of chiral building blocks for active pharmaceutical ingredients (APIs).
• Cross-Coupling Catalysis: Facilitates asymmetric cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig amination, for C-C and C-N bond formation.
• Agrochemical Synthesis: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Production: Enables the synthesis of specialty chemicals with high optical purity for flavors, fragrances, and electronic materials.

Basic Information

Product Name	(R)-(+)-2,2'-Bis(Dicyclobutylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl
CAS No.	150971-51-0
Molecular Formula	C30H40O2P2
Molecular Weight	494.60 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-DTBM-SegPhos; (R)-(+)-DTBM-SegPhos; (R)-5,5'-Bis(dicyclobutylphosphino)-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Bis(dicyclobutylphosphino)-6,6'-dimethoxybiphenyl; (R)-DTBM-Segphos Ligand; (R)-DTBM-Segphos; (R)-DTBM-SegPhos (Ligand)
EINECS	Contact for details

Quality Control

Our (R)-(+)-2,2'-Bis(Dicyclobutylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral analysis, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with full characterization data are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is easily oxidized and light-sensitive; handling in a glovebox or under inert conditions is recommended for optimal performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.