Description

(R)-(+)-2,2'-Bis(Di-I-Propylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand, a critical component in asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in the synthesis of complex pharmaceutical intermediates and fine chemicals, leading to products with higher efficacy and fewer side effects. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-performance ligands for transition metal-catalyzed cross-coupling and hydrogenation reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond formations, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high enantioselectivity.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs) for oncology, CNS, and cardiovascular drugs.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Enables the production of specialty flavors, fragrances, and advanced material precursors with defined chirality.
• Catalyst Development & Screening: Serves as a benchmark ligand in R&D for developing new asymmetric catalytic processes.

Basic Information

Product Name	(R)-(+)-2,2'-Bis(Di-I-Propylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97%
CAS No.	150971-45-2
Molecular Formula	C28H44O2P2
Molecular Weight	474.60 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-5,5'-Bis(diisopropylphosphino)-4,4'-bi-1,3-benzodioxole; (R)-(+)-DTBM-SEGPHOS; (R)-DTBM-SegPhos; (R)-3,3'-Dimethoxy-2,2'-bis(diisopropylphosphino)-5,5',6,6'-tetramethyl-4,4'-biphenyldiol (common misnomer); (R)-DTBM-Segphos ligand; SEGPHOS derivative, DTBM-substituted; (R)-DTBM-SegPhos ligand
EINECS	Contact for details

Quality Control

Our (R)-(+)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and ICP-MS for trace metal analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided to maintain catalytic activity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%
Trace Metals (ICP-MS)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.