Description

(S)-(-)-2,2'-Bis(Di-I-Propylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl is a high-purity, chiral bisphosphine ligand essential for advanced asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating enantiomerically pure products.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Synthesis: Facilitates the creation of enantiopure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric carbon-carbon and carbon-heteroatom bond-forming reactions for specialty molecules.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic pathways.
• Ligand for Transition Metal Complexes: Forms active catalysts with rhodium, ruthenium, and iridium for various asymmetric transformations.

Basic Information

Product Name	(S)-(-)-2,2'-Bis(Di-I-Propylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl (Min. 97%)
CAS No.	150971-43-0
Molecular Formula	C28H44O2P2
Molecular Weight	474.59 g/mol
Synonyms	(S)-(-)-BIPHEP; (S)-2,2'-Bis(diisopropylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (S)-(-)-6,6'-Dimethoxy-2,2'-bis(diisopropylphosphino)biphenyl; (S)-(-)-Bis(diisopropylphosphino)-6,6'-dimethoxybiphenyl; (S)-DTBM-BIPHEP; (S)-DTBM-SEGPHOS (related structural analog); (S)-BIPHEP ligand; LICAND (S)-BIPHEP(OMe)2
EINECS	Contact for details

Quality Control

Our (S)-(-)-2,2'-Bis(Di-I-Propylphosphino)-6,6'-Dimethoxy-1,1'-Biphenyl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Enantiomeric Excess (ee)	Min. 99.0%
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.