Description

(S)-(6,6'-Dimethoxy-[1,1'-Biphenyl]-2,2'-Diyl)Bis(Bis(3,5-Bis(Trimethylsilyl)Phenyl)Phosphine) is a sophisticated, chiral bisphosphine ligand designed for high-performance asymmetric catalysis. Its value lies in its sterically demanding and electron-rich structure, which provides exceptional enantioselectivity and reactivity in transition metal-catalyzed transformations. This compound is essential for R&D chemists and process engineers in the pharmaceutical and fine chemical industries seeking to develop efficient, stereoselective synthetic routes to active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric Cross-Coupling Reactions: Enables highly selective C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, for constructing complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Used in the key catalytic steps for manufacturing chiral drugs, including those for cardiovascular, central nervous system, and oncological therapies.
• Process Chemistry & Scale-up: Employed in the development and optimization of commercial-scale manufacturing processes for high-value chiral compounds.
• Academic & Industrial R&D: A valuable tool for discovering new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Catalyst Library Development: Serves as a key component in high-throughput screening libraries for identifying optimal catalyst systems for specific transformations.

Basic Information

Item	Details
Product Name	(S)-(6,6'-Dimethoxy-[1,1'-Biphenyl]-2,2'-Diyl)Bis(Bis(3,5-Bis(Trimethylsilyl)Phenyl)Phosphine)
CAS No.	150971-37-2
Molecular Formula	C68H94O2P2Si8
Molecular Weight	1244.10 g/mol
Synonyms	(S)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-bis(trimethylsilyl)phenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-DTBM-Segphos; (S)-3,3'-Dimethoxy-4,4'-bis[bis(3,5-bis(trimethylsilyl)phenyl)phosphino]-1,1'-biphenyl; DTBM-SEGPHOS (S-form); SEGPHOS derivative, DTBM-substituted; Ligand for asymmetric hydrogenation
EINECS	Contact for details

Quality Control

Every batch of our (S)-DTBM-SEGPHOS is manufactured and tested under strict quality management systems to ensure exceptional purity and consistent chiral integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), and residual metal content. Our quality protocols are designed to meet the stringent requirements of cGMP and pharmaceutical R&D, ensuring reliability for your most critical catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized and moisture-sensitive; therefore, handling and packaging should be performed in a controlled, dry environment to maintain optimal performance.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.