Description

Kaliotoxin-1 Recombinant Expressed In is a high-purity, recombinantly expressed peptide toxin that selectively blocks specific potassium ion channels. This precision makes it an invaluable research tool for studying ion channel physiology, neurological signaling pathways, and related drug discovery. It is primarily utilized by academic researchers, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, electrophysiology, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective blocker of voltage-gated potassium channels (e.g., Kv1.1, Kv1.3), it is essential for patch-clamp and other electrophysiological studies to understand neuronal excitability and synaptic transmission.
• Drug Discovery & Screening: Used in high-throughput assays to identify and characterize new compounds that modulate potassium channel activity for potential treatments in autoimmune diseases, neurological disorders, and cardiac conditions.
• Ion Channel Characterization: Serves as a specific pharmacological tool to define the subunit composition and functional properties of native and recombinant potassium channels expressed in cell lines.
• Biochemical Studies: Employed in binding studies and structural biology research to investigate toxin-channel interactions and guide the design of channel-specific modulators.
• Safety Pharmacology: Applied in preclinical testing to assess the potential off-target cardiac or neurological effects of new drug candidates related to potassium channel inhibition.

Basic Information

Product Name	Kaliotoxin-1 Recombinant Expressed In
CAS No.	150769-72-5
Molecular Formula	C185H281N53O51S6
Molecular Weight	~4298.9 g/mol
Synonyms	Kaliotoxin 1; KTX; KTX-1; Potassium channel toxin α-KTx 3.7; Toxin KTX; Charybdotoxin-like toxin from Androctonus mauretanicus mauretanicus; Recombinant Kaliotoxin-1; rKTX-1; Synthetic Kaliotoxin-1
EINECS	Contact for details

Quality Control

Our recombinant Kaliotoxin-1 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry for identity confirmation, and functional activity assays in validated electrophysiological or binding models. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee the product meets the exacting standards required for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store lyophilized powder at -20°C or below. For long-term storage, keep at -70°C. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -20°C or lower. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch on COA
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.