Description

4-Keto 9-Cis Retinoic Acid is a synthetic derivative of vitamin A, specifically a ketone-modified form of 9-cis-retinoic acid. This compound is of significant interest in advanced pharmaceutical research and development due to its role as a selective ligand for retinoid receptors. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics targeting dermatological conditions, oncology, and metabolic disorders.

Application

• Pharmaceutical R&D Intermediate: A key building block in the synthesis of novel retinoid-based drugs for targeted therapies.
• Biochemical Research: Used as a reference standard and active compound in studies of retinoid receptor (RAR/RXR) signaling pathways and gene expression.
• Dermatology Research: Investigated for its potential effects on cellular differentiation and proliferation in skin-related studies.
• Oncology Research: Explored for its role in modulating cell growth and apoptosis in cancer cell line studies.
• Metabolic Disorder Studies: Utilized in research focusing on the influence of retinoids on lipid metabolism and insulin sensitivity.

Basic Information

Product Name	4-Keto 9-Cis Retinoic Acid
CAS No.	150737-18-1
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.43 g/mol
Synonyms	9-Cis-4-Oxoretinoic Acid; 9-cis-4-Ketoretinoic Acid; 4-Oxo-9-cis-retinoic Acid; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid, 4-Oxo-; 4-Keto-9-cis-RA; 9-cis-Retinoic Acid 4-Ketone
EINECS	Contact for details

Quality Control

Our 4-Keto 9-Cis Retinoic Acid is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and MS. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled temperature of -20°C or below for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.