Description

(D-Phe12,Nle21·38,α-Me-Leu37)-Crf (12-41) (Human, Rat) is a synthetic peptide fragment of corticotropin-releasing factor (CRF), specifically engineered with specific amino acid substitutions to enhance its stability and biological activity profile. This compound is a critical research tool for investigating the CRF receptor system, which plays a central role in the body's stress response, anxiety, and endocrine regulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, endocrinology, and drug discovery programs.

Application

• Neuroscience Research: As a potent CRF receptor ligand for studying stress-related behaviors, anxiety disorders, and depression in preclinical models.
• Endocrinology Studies: For investigating the hypothalamic-pituitary-adrenal (HPA) axis regulation and the release of adrenocorticotropic hormone (ACTH).
• Drug Discovery & Development: Serving as a reference standard or a key pharmacophore in the screening and development of novel CRF receptor antagonists or agonists.
• Biochemical Assays: Used in receptor binding assays, functional cellular assays (e.g., cAMP measurement), and signal transduction pathway analysis.
• Metabolic Research: Exploring the role of CRF in appetite regulation, energy balance, and gastrointestinal function.
• Veterinary Research: Applied in studies of stress physiology and related disorders in animal health sciences.

Basic Information

Product Name	(D-Phe12,Nle21·38,α-Me-Leu37)-Crf (12-41) (Human, Rat)
CAS No.	150646-45-0
Molecular Formula	C164H256N44O43
Molecular Weight	~ 3530.0 g/mol
Synonyms	[D-Phe12,Nle21,38, α-Me-Leu37]-CRF (12-41); Corticotropin-Releasing Factor (12-41), [D-Phe12,Nle21,38,α-Me-Leu37]-; CRF (12-41) fragment, modified; Sauvagine/urotensin/CRF-like peptide analog; Astressin analog; CRF receptor research peptide; h/rCRF(12-41) analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Identity is confirmed by mass spectrometry (MS) and analytical HPLC. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below in a dry environment. Once reconstituted in appropriate buffer, aliquot and store at -20°C or -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.