Description

(R)-(+)-4-Bromomandelonitrile is a high-purity chiral building block and synthetic intermediate of significant importance in asymmetric synthesis. Its value lies in its brominated mandelonitrile structure, which serves as a versatile precursor for the preparation of enantiomerically pure pharmaceuticals, agrochemicals, and fine chemicals. This compound is particularly needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical and advanced materials sectors seeking to introduce chiral complexity into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular drug research.
• Asymmetric Catalyst Ligand Precursor: Used in the development and synthesis of novel chiral ligands for transition metal catalysis.
• Agrochemical Synthesis: Serves as a building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, focusing on new asymmetric carbon-carbon bond-forming reactions.
• Material Science: Potential precursor for chiral monomers or dopants in advanced polymeric and liquid crystalline materials.

Basic Information

Product Name	(R)-(+)-4-Bromomandelonitrile
CAS No.	150521-30-5
Molecular Formula	C9H6BrNO
Molecular Weight	224.05 g/mol
Synonyms	(R)-4-Bromomandelonitrile; (R)-(+)-4-Bromo-α-hydroxybenzeneacetonitrile; (R)-4-Bromophenylglycolonitrile; (R)-α-Hydroxy-4-bromobenzyl cyanide; (R)-(+)-p-Bromomandelonitrile; (R)-4-Bromo-2-hydroxy-2-phenylacetonitrile; (R)-Mandelonitrile, 4-bromo-; (R)-O-(4-Bromophenyl)glycolonitrile
EINECS	Contact for details

Quality Control

Our (R)-(+)-4-Bromomandelonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Specification available upon request
Specific Rotation	Specification available upon request
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.