Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho(Tempo)Choline is a specialized, spin-labeled phospholipid derivative, widely recognized for its role as a paramagnetic probe in biophysical research. This compound matters because it enables the study of membrane dynamics, lipid-protein interactions, and oxidative processes using advanced techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic developers working on lipidomics, drug delivery systems, and the fundamental biophysics of cell membranes.

Application

• Membrane Biophysics Research: As a spin-label for probing membrane fluidity, phase transitions, and lateral organization using EPR spectroscopy.
• Lipid-Protein Interaction Studies: To investigate the binding and conformational changes of membrane-associated proteins and peptides.
• Oxidative Stress & Lipid Peroxidation Models: Serving as a sensitive reporter for reactive oxygen species (ROS) activity within lipid bilayers.
• Drug Delivery System Development: Used in the formulation and characterization of liposomes and other lipid-based nanocarriers to track stability and fusion events.
• Diagnostic Assay Development: Potential use in developing EPR-based assays for detecting membrane-related disorders or oxidative damage.
• Model Membrane Systems: A key component in creating well-defined lipid bilayers (e.g., vesicles, supported bilayers) for controlled experimental systems.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho(Tempo)Choline
CAS No.	150480-57-2
Molecular Formula	C₅₀H₉₈NO₈P
Molecular Weight	872.30 g/mol
Synonyms	DOPC-Tempo; 1,2-Dioleoyl-sn-glycero-3-phospho(tempo)choline; Tempo-DOPC; 1,2-Dioleoylphosphatidylcholine Tempo-labeled; 2,2,6,6-Tetramethylpiperidine-1-oxyl-labeled DOPC; 4-(N,N-Dimethyl-N-(2-hydroxyethyl))ammonium-2,2,6,6-tetramethylpiperidine-1-oxyl labeled DOPC; Phosphatidylcholine, 1,2-dioleoyl-sn-glycero-3-phospho-(2,2,6,6-tetramethylpiperidine-1-oxyl-4-ylmethyl)ethyl ester
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho(Tempo)Choline is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Spin-Label Integrity (EPR)	Active radical content ≥ 90%
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.