Description

2,4-Dichloroquinoline-6-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is prized for its dual reactive sites, enabling precise molecular construction in the development of complex chemical entities. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various biologically active quinoline derivatives, including potential kinase inhibitors, antimicrobial agents, and anticancer compounds.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging the quinoline scaffold's bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs) due to its rigid, planar structure and electron-withdrawing groups.
• Dye and Pigment Chemistry: Employed in the synthesis of specialized quinoline-based dyes and colorants for technical applications.
• Cross-Coupling Reactions: The chlorine atoms at the 2 and 4 positions make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and Negishi couplings for library synthesis.
• Nucleophilic Substitution: The nitrile group at the 6-position offers a versatile handle for further functionalization into amides, acids, and heterocycles.

Basic Information

Product Name	2,4-Dichloroquinoline-6-Carbonitrile
CAS No.	150453-93-3
Molecular Formula	C10H4Cl2N2
Molecular Weight	223.06 g/mol
Synonyms	6-Cyano-2,4-dichloroquinoline; 2,4-Dichloro-6-quinolinecarbonitrile; 2,4-Dichloro-6-cyanoquinoline; Quinoline-6-carbonitrile, 2,4-dichloro-; 150453-93-3; 2,4-Dichlor-chinolin-6-carbonitril (German); 2,4-ジクロロキノリン-6-カルボニトリル (Japanese)
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloroquinoline-6-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality protocol includes identity confirmation by spectroscopic methods and purity determination by HPLC. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can support development and production needs across various grades, from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.