Description

ω-Conotoxin Svib is a selective peptide neurotoxin derived from the venom of cone snails, with the CAS registry number 150433-82-2. This compound is a highly valuable research tool for studying N-type voltage-gated calcium channels (Cav2.2) in neuronal signaling pathways. It is essential for pharmaceutical R&D, academic neuroscience, and biotechnology sectors focused on pain research, neurological disorders, and ion channel pharmacology.

Application

• Neuroscience Research: A critical pharmacological tool for selectively blocking N-type calcium channels to study synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Pathway Investigation: Used in preclinical research to elucidate the role of Cav2.2 channels in nociception and to validate targets for novel analgesic drug development.
• Ion Channel Profiling: Employed in electrophysiology studies (e.g., patch-clamp) and functional assays to characterize channel subtypes and screen for potential modulators.
• Biochemical Reagent: Serves as a standard or reference compound in assay development, receptor binding studies, and quality control for related bioproducts.
• Drug Discovery: Supports target validation and mechanistic studies within pharmaceutical R&D programs aimed at developing new therapies for chronic pain and neurological conditions.

Basic Information

Product Name	ω-Conotoxin Svib
CAS No.	150433-82-2
Molecular Formula	C₁₀₂H₁₆₈N₃₄O₃₂S₇
Molecular Weight	2639.1 g/mol
Synonyms	ω-Conotoxin SVIB; Conotoxin ω-Svib; ω-Conotoxin SVIB; ω-CTx-Svib; SNX-325; Ctx ω-Svib; N-type calcium channel blocker ω-Svib; Conus striatus toxin ω-Svib
EINECS	Contact for details

Quality Control

Our ω-Conotoxin Svib is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional activity data. We adhere to rigorous quality protocols suitable for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity	Specified by COA (e.g., IC₅₀ in functional assay)
Solubility	Soluble in aqueous buffers or dilute acetic acid
Endotoxin Level	< 1.0 EU/μg (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.