Description

Hexanoic Acid, 6-[[1-Oxo-3-(2-Pyridinyldithio)Propyl]Amino]-, 2,5-Dioxo-3-Sulfo-1-Pyrrolidinyl Ester is a specialized, heterobifunctional crosslinking reagent designed for advanced bioconjugation and protein modification. Its core value lies in its unique structure, which incorporates a reactive NHS ester for amine coupling and a cleavable pyridyldithiol group for thiol-specific attachment, enabling the creation of reversible or cleavable linkages. This compound is essential for researchers and manufacturers in biopharmaceutical development, proteomics, and diagnostic assay production who require precise and controlled protein labeling.

Application

• Bioconjugation and Crosslinking: For creating reversible crosslinks between proteins, peptides, and other biomolecules containing amine and thiol groups.
• Antibody-Drug Conjugate (ADC) Development: As a linker-payload intermediate for constructing cleavable ADCs, facilitating targeted drug delivery.
• Surface Immobilization: Functionalizing sensor chips, microarrays, and nanoparticles with biomolecules for biosensing and diagnostic applications.
• Affinity Chromatography: Synthesis of cleavable affinity ligands for the purification and subsequent release of target proteins.
• Proteomics Research: Labeling and tagging of proteins for mass spectrometry analysis, structural studies, and interaction mapping.
• Controlled Release Systems: Designing drug delivery carriers where the active agent is released upon exposure to specific reducing conditions.

Basic Information

Product Name	Hexanoic Acid, 6-[[1-Oxo-3-(2-Pyridinyldithio)Propyl]Amino]-, 2,5-Dioxo-3-Sulfo-1-Pyrrolidinyl Ester
CAS No.	150244-18-1
Molecular Formula	C18H22N4O8S3
Molecular Weight	518.58 g/mol
Synonyms	N-Succinimidyl 3-(2-pyridyldithio)propionamidocaproate sulfonate; SPDP Sulfonate; Sulfo-LC-SPDP; 6-((3-(2-Pyridinyldithio)propanamido)hexanoic acid 2,5-dioxopyrrolidin-1-yl ester 3-sulfonate; NHS-PEG2-SPDP Sulfonate; Heterobifunctional Crosslinker, Sulfo-NHS-SS-Pyridine; N-Succinimidyl 6-[3'-(2-pyridyldithio)propionamido]hexanoate sulfonate; LC-SPDP Sulfonate
EINECS	Contact for details

Quality Control

Our bioconjugation-grade products are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting research and development under GMP/GLP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF
Functional Activity	Conforms (by assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.