Description

trans-Haloperidol n-Oxide is a high-purity chemical reference standard and a key oxidative metabolite of the antipsychotic drug haloperidol. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical methods. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of haloperidol metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and safety profile of haloperidol.
• Analytical Method Development: Serves as a critical standard for developing and validating high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and other analytical techniques.
• Impurity Profiling: Employed in the identification and control of potential oxidative degradants in haloperidol active pharmaceutical ingredient (API) and finished drug products.
• Pharmacology Studies: Used to assess the pharmacological activity and potential toxicity of haloperidol metabolites.
• Regulatory Compliance: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization of drug-related substances.

Basic Information

Product Name	trans-Haloperidol n-Oxide
CAS No.	150214-93-0
Molecular Formula	C21H23ClFNO3
Molecular Weight	391.87 g/mol
Synonyms	Haloperidol N-Oxide (trans-); 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone N-Oxide; 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-, 1-oxide; Haloperidol 1-Oxide; Haloperidol N-Oxide (E-Isomer); trans-Haloperidol 1-Oxide; Haloperidol Metabolite II (N-Oxide)
EINECS	Contact for details

Quality Control

Our trans-Haloperidol n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.