Description

Propanenitrile, 3-(2-Pyridinyldithio)- (9Ci) is a specialized bifunctional chemical reagent featuring a reactive nitrile group and a cleavable disulfide bond linked to a pyridine ring. This compound is valued for its role as a versatile heterobifunctional crosslinker and a key intermediate in the synthesis of complex molecules, particularly in bioconjugation and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for creating targeted drug conjugates, modifying biomolecules, and developing novel chemical entities.

Application

• Bioconjugation Reagent: Used as a heterobifunctional crosslinker for coupling proteins, peptides, or antibodies to other molecules, drugs, or solid supports via its distinct reactive sites.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted therapies and antibody-drug conjugates (ADCs).
• Prodrug Synthesis: Employed in the design and synthesis of prodrugs where a disulfide linkage provides a mechanism for controlled drug release in specific biological environments.
• Polymer Functionalization: Utilized to introduce reactive pyridyldithiol groups onto polymer backbones for creating smart, stimuli-responsive materials or functional surfaces.
• Chemical Biology Tool: Acts as a key reagent for labeling, modifying, or studying biomolecular interactions and cellular processes.
• Material Science Research: Applied in the development of advanced nanomaterials and surface coatings where controlled molecular attachment is required.

Basic Information

Item	Details
Product Name	Propanenitrile, 3-(2-Pyridinyldithio)- (9Ci)
CAS No.	149997-76-2
Molecular Formula	C8H8N2S2
Molecular Weight	196.29 g/mol
Synonyms	3-(2-Pyridyldithio)propionitrile; 2-Pyridyl 3-Cyanopropyl Disulfide; S-(2-Cyanoethyl) 2-Pyridyl Disulfide; 3-(Pyridin-2-yldisulfanyl)propanenitrile; PDP; Pyridyl Disulfide Propionitrile; N-(2-Cyanoethyl)-2-pyridyl disulfide; 2-Pyridyl disulfide propionitrile
EINECS	Contact for details

Quality Control

Our Propanenitrile, 3-(2-Pyridinyldithio)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.