Description

Azimilide is a potent class III antiarrhythmic agent, specifically a potassium channel blocker, known for its unique dual-channel inhibition of both the slow and rapid components of the delayed rectifier potassium current. This mechanism of action makes it a compound of significant interest for the research and development of novel cardiac therapeutics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract research organizations (CROs) focused on cardiovascular disease.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new antiarrhythmic drugs.
• Cardiac Electrophysiology Studies: Used as a pharmacological tool in in vitro and in vivo research to study potassium channel function and cardiac repolarization.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify and characterize compounds with similar ion channel blocking activity.
• Metabolism and Pharmacokinetics (DMPK) Studies: Utilized to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of related chemical entities.
• Analytical Method Development: Acts as a critical standard for developing and validating HPLC, LC-MS, and other analytical methods for purity and potency testing.
• Preclinical Safety & Toxicology: Used in safety pharmacology studies to assess the cardiac safety profile of new chemical entities.

Basic Information

Product Name	Azimilide
CAS No.	149908-53-2
Molecular Formula	C20H27N5O2S
Molecular Weight	401.53 g/mol
Synonyms	NE-10064; Azimilide dihydrochloride (salt form precursor); 4-[[(5,6-Dichloro-1H-benzimidazol-2-yl)amino]-4-oxobutyl]-N-(phenylmethyl)-1-piperazineacetamide; 1-[4-[4-(Benzylcarbamoylmethyl)piperazin-1-yl]-4-oxobutyl]-5,6-dichloro-1H-benzimidazol-2-amine
EINECS	Contact for details

Quality Control

Our Azimilide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.