Description

Azimilide is a potent class III antiarrhythmic agent, specifically a potassium channel blocker, known for its unique pharmacological profile. This compound is of significant interest for its potential in the research and development of novel cardiovascular therapeutics. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on cardiac electrophysiology and drug discovery.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of antiarrhythmic drugs.
• Cardiac Electrophysiology Studies: Used in in vitro and in vivo research to study the mechanisms of potassium channel blockade and its effects on cardiac action potential duration.
• Preclinical Investigation: Serves as a critical compound for pharmacokinetic, pharmacodynamic, and toxicology studies in animal models.
• Biochemical Assay Development: Employed as a tool compound in high-throughput screening (HTS) assays to identify and validate new therapeutic targets related to heart rhythm disorders.
• Academic Research: Utilized in university laboratories for fundamental research into ion channel function and the pathophysiology of atrial and ventricular arrhythmias.
• Chemical Synthesis: Acts as a sophisticated building block for medicinal chemists synthesizing analogs to explore structure-activity relationships (SAR).

Basic Information

Product Name	Azimilide
CAS No.	149888-94-8
Molecular Formula	C₂₂H₂₇N₅O₂S
Molecular Weight	425.55 g/mol
Synonyms	NE-10064; 1-[[5-(4-Fluorophenyl)-2-furanyl]methylene]amino]-3-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]urea; Azimilide Dihydrochloride (salt form); 4-[[[[[5-(4-Fluorophenyl)-2-furanyl]methylene]amino]carbonyl]amino]-N-methyl-N-(1-methyl-4-piperidinyl)benzamide
EINECS	Contact for details

Quality Control

Our Azimilide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-purity standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.