Description

Methyl-n-tert-Butyloxycarbonyl-Amino-4,4'-Biphenyl-R-Alanine is a sophisticated chiral amino acid derivative featuring a biphenyl core, designed for advanced synthetic applications. This compound matters as a high-value building block for medicinal chemistry, enabling the precise construction of complex peptide-like structures and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring rigid, aromatic scaffolds. Its defined stereochemistry at the R-configured α-carbon ensures consistent and predictable outcomes in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for non-natural peptide mimetics.
• Peptidomimetic Synthesis: Used to incorporate a rigid, hydrophobic biphenyl moiety into peptide chains to modulate bioavailability and receptor binding affinity.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors targeting specific enzymes.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged molecules for studying biological pathways and protein interactions.
• Asymmetric Catalysis Research: Acts as a chiral ligand precursor or a test substrate in methodological development.
• Material Science: Potential monomer for creating specialized polymers with unique optical or structural properties.

Basic Information

Item	Detail
Product Name	Methyl-n-tert-Butyloxycarbonyl-Amino-4,4'-Biphenyl-R-Alanine
CAS No.	149818-98-4
Molecular Formula	C22H27NO4
Molecular Weight	369.46 g/mol
Synonyms	Boc-4-Biphenyl-R-Alanine Methyl Ester; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-[1,1'-biphenyl]-4-propanoate; Methyl (R)-2-[(tert-Butoxycarbonyl)amino]-3-(4-biphenylyl)propanoate; Boc-(R)-Biphenylalanine-OMe; N-Boc-4,4'-Biphenyl-R-alanine methyl ester; (R)-2-(tert-Butoxycarbonylamino)-3-(biphenyl-4-yl)propionic acid methyl ester; N-(tert-Butoxycarbonyl)-4,4'-biphenyl-R-alanine methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl-n-tert-Butyloxycarbonyl-Amino-4,4'-Biphenyl-R-Alanine adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and optical rotation analyses. We support compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee (R-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.