Description

5-Pyrimidinecarboxylicacid,2-Amino-4-(Trifluoromethyl)-(9Ci) is a high-value trifluoromethyl-substituted pyrimidine derivative, serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the metabolically stable and lipophilic trifluoromethyl group into target molecules, which is a key strategy in modern medicinal chemistry for modulating pharmacokinetic properties. Pharmaceutical and agrochemical researchers need this intermediate for the development of novel active ingredients, particularly in the creation of enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the design and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and activity-based protein profiling (ABPP) reagents to study enzyme function.
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials that require specific fluorine-containing aromatic units.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	5-Pyrimidinecarboxylicacid,2-Amino-4-(Trifluoromethyl)-(9Ci)
CAS No.	149771-23-3
Molecular Formula	C6H4F3N3O2
Molecular Weight	207.11 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)pyrimidine-5-carboxylic acid; 2-Amino-4-trifluoromethyl-5-pyrimidinecarboxylic acid; 4-(Trifluoromethyl)-2-aminopyrimidine-5-carboxylic acid; 5-Carboxy-2-amino-4-trifluoromethylpyrimidine; 2-Amino-4-(trifluoromethyl)-5-pyrimidinecarboxylic acid; 149771-23-3; 2-Amino-4-trifluoromethylpyrimidine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarboxylicacid,2-Amino-4-(Trifluoromethyl)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and MS. We are committed to meeting the stringent requirements of our global clientele in the fine chemical and pharmaceutical sectors.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.