Description

Vps35 Protein CAS NO 149769-26-6 is a high-purity recombinant protein that serves as a critical component of the retromer complex, essential for intracellular protein sorting and trafficking. This product is vital for researchers and developers in the life sciences sector who require reliable, well-characterized biological reagents for mechanistic studies. It is primarily utilized in biochemical research, drug discovery, and the development of diagnostic assays targeting neurodegenerative pathways.

Application

• Biochemical Research: Used as a key reagent in studies of endosomal sorting, retrograde transport, and retromer complex function.
• Drug Discovery & Target Validation: Employed in high-throughput screening (HTS) assays and target engagement studies for neurological disorders like Parkinson's and Alzheimer's disease.
• Protein-Protein Interaction Studies: Serves as a crucial component in pull-down assays, co-immunoprecipitation (Co-IP), and surface plasmon resonance (SPR) to map interactomes.
• Diagnostic Development: Acts as an antigen or standard in the development of immunoassays and biosensors for research purposes.
• Cell Biology & Imaging: Utilized in cellular reconstitution experiments and as a tool to study trafficking defects in genetically modified cell lines.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focusing on cell biology, neurobiology, and molecular genetics.

Basic Information

Product Name	Vps35 Protein
CAS No.	149769-26-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	VPS35; Vacuolar Protein Sorting-Associated Protein 35; Retromer Complex Component VPS35; PARK17; hVPS35; VPS35 Retromer Complex Component; VPS35 Human; Recombinant Human VPS35 Protein; Vps35p
EINECS	Contact for details

Quality Control

Our Vps35 Protein is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Identification (Mass Spec)	Conforms
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by functional assay
Protein Concentration	As per COA
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.