Description

(R)-2-Amino-3-Pyrazol-1-Yl-Propionic Acid CAS NO 149655-71-0 is a high-purity, non-proteinogenic amino acid derivative featuring a pyrazole substituent, which serves as a key chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex molecules with defined stereochemistry, which is critical for developing bioactive compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-quality, enantiomerically pure intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid motifs into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with specific chiral activity.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Biochemical Probe Synthesis: Useful for creating labeled compounds and molecular probes for studying biological pathways and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring enantiomeric purity and reliable supply chain integrity.

Basic Information

Product Name	(R)-2-Amino-3-Pyrazol-1-Yl-Propionic Acid
CAS No.	149655-71-0
Molecular Formula	C6H9N3O2
Molecular Weight	155.16 g/mol
Synonyms	(R)-2-Amino-3-(1H-pyrazol-1-yl)propanoic acid; (R)-2-Amino-3-(pyrazol-1-yl)propionic acid; (R)-1H-Pyrazole-1-propanoic acid, α-amino-; D-2-Amino-3-pyrazol-1-ylpropionic acid; (R)-3-(1H-Pyrazol-1-yl)-2-aminopropanoic acid; (R)-Amino-pyrazolyl-propionic acid; (R)-APPA; (R)-149655-71-0
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-3-Pyrazol-1-Yl-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.