Description

6,6'-[[(1R,3R)-1,3-Dimethyl-1,3-Propanediyl]Bis(Oxy)]Bis[4,8-Bis(T-Butyl)-2,10-Dimethoxy-Bibenzo[D,F][1,3,2]Dioxaphosphepin is a sophisticated chiral phosphite ligand, a key component in asymmetric catalysis. This compound matters for its ability to impart high enantioselectivity and activity in transition metal-catalyzed reactions, enabling the production of optically pure intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for synthesizing chiral active pharmaceutical ingredients (APIs) and advanced materials.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical synthesis.
• Catalyst component for enantioselective C-C bond formation (e.g., allylic alkylation).
• Used in the development of high-performance catalysts for the production of specialty and fine chemicals.
• Critical for research into asymmetric synthesis methodologies in academic and industrial laboratories.
• Employed in the synthesis of optically active natural products and complex organic molecules.
• Facilitates process optimization for the commercial-scale manufacturing of chiral compounds.

Basic Information

Product Name	6,6'-[[(1R,3R)-1,3-Dimethyl-1,3-Propanediyl]Bis(Oxy)]Bis[4,8-Bis(T-Butyl)-2,10-Dimethoxy-Bibenzo[D,F][1,3,2]Dioxaphosphepin
CAS No.	149646-83-3
Molecular Formula	C52H68O10P2
Molecular Weight	915.02 g/mol
Synonyms	(R,R)-Benzene-1,3-diol, 4,4'-(1R,3R)-1,3-dimethyl-1,3-propanediylbis(oxy)bis[2,6-bis(1,1-dimethylethyl)-, cyclic bis(4-methylbenzenesulfonate) (9CI); (R,R)-2,2'-[[(1R,3R)-1,3-Dimethyl-1,3-propanediyl]bis(oxy)]bis[4,6-bis(1,1-dimethylethyl)phenyl] cyclic bis(4-methylbenzenesulfonate); (R,R)-Me-DuPhos ligand derivative; Chiral phosphite ligand; Biphenol-based phosphite ligand; (R,R)-BIPHEP-type ligand; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, enantiomeric purity, and overall assay. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, maintaining the material under an inert atmosphere (argon or nitrogen) is recommended to preserve efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.