Description

Mog (35-55) CAS NO 149635-73-4 is a high-purity synthetic peptide sequence, specifically the 35-55 fragment of the Mog protein. This compound is a critical research tool for immunological and neurological studies, offering precise molecular targeting. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on autoimmune diseases and central nervous system research.

Application

• Experimental Autoimmune Encephalomyelitis (EAE) Model Induction: A key antigen for inducing and studying EAE, a standard animal model for multiple sclerosis (MS).
• T-Cell Epitope Mapping: Used to identify and characterize specific T-cell receptor interactions and epitopes relevant to demyelinating diseases.
• Immunological Assay Development: Serves as a critical coating antigen or standard in ELISA, ELISPOT, and other immunoassays to detect antigen-specific antibodies or T-cells.
• Drug Discovery & Vaccine Research: Employed in screening and evaluating potential therapeutic compounds or vaccine candidates targeting myelin oligodendrocyte glycoprotein (MOG).
• Neuroimmunology Research: Fundamental for investigating the role of MOG in the pathogenesis of MS and other neuroinflammatory disorders.
• Specificity Validation for Diagnostic Reagents: Used to validate the specificity of antibodies, kits, and other reagents designed for MOG-associated disease detection.

Basic Information

Product Name	Mog (35-55)
CAS No.	149635-73-4
Molecular Formula	C105H165N31O33
Molecular Weight	~2350.6 g/mol
Synonyms	MOG (35-55); Myelin Oligodendrocyte Glycoprotein Peptide (35-55); MOG35-55; MOG Peptide Fragment 35-55; MOG p35-55; MEVGWYRSPFSRVVHLYRNGK; Encephalitogenic MOG Peptide; MOG Antigen
EINECS	Contact for details

Quality Control

Our Mog (35-55) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity, Mass Spectrometry (MS) for identity confirmation, and Amino Acid Analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.