Description

Platelet Derived Growth Factor Fragment 742-758 is a synthetic peptide fragment corresponding to a specific sequence of the Platelet-Derived Growth Factor (PDGF) protein. This compound is a critical research-grade biochemical tool for studying cellular signaling pathways, particularly those involving cell growth, proliferation, and chemotaxis. It is essential for researchers and developers in the fields of biomedical research, pharmaceutical development, and cell biology who require high-purity, well-characterized peptides for experimental and pre-clinical studies.

Application

• Biochemical Research: Used as a specific ligand to study PDGF receptor binding, activation, and downstream signal transduction mechanisms.
• Cell Culture Studies: Applied in vitro to stimulate the proliferation and migration of fibroblasts, glial cells, and other connective tissue cells.
• Wound Healing Models: Investigated in research models to understand and potentially enhance tissue repair and regeneration processes.
• Drug Discovery & Development: Serves as a reference standard or a tool compound for screening and developing therapeutic agents targeting the PDGF pathway.
• Receptor Characterization: Employed in assays to characterize PDGF receptor subtypes (α and β) and their specific interactions.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring growth factor biology and related pathologies.

Basic Information

Product Name	Platelet Derived Growth Factor Fragment 742-758
CAS No.	149635-67-6
Molecular Formula	C89H138N24O26
Molecular Weight	1912.2 g/mol
Synonyms	PDGF (742-758); PDGF Fragment 742-758; Human PDGF-BB (742-758); Platelet-Derived Growth Factor B-Chain (742-758); H-Ile-Ile-His-Pro-Asp-Lys-Thr-Lys-Asp-Glu-Leu-Tyr-Val-Lys-Leu-Pro-Met-OH; Ile-Ile-His-Pro-Asp-Lys-Thr-Lys-Asp-Glu-Leu-Tyr-Val-Lys-Leu-Pro-Methionine; PDGF Peptide Fragment; c-sis/PDGF-2 (742-758)
EINECS	Contact for details

Quality Control

Our Platelet Derived Growth Factor Fragment 742-758 is manufactured under stringent conditions to ensure the highest standards of purity and consistency. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee product integrity for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values (±10%)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.