Description

10-Decarbamoylmitomycin C-N(2)-Deoxyguanosine-Adduct is a chemically defined adduct formed between the potent antitumor antibiotic mitomycin C and the DNA nucleoside deoxyguanosine. This compound is of significant value as a reference standard and research tool for studying the molecular mechanisms of DNA alkylation and cross-linking by mitomycin derivatives. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers engaged in oncology drug development, DNA damage research, and bioanalytical method validation.

Application

• Biochemical Research: Used as a critical reference standard to investigate the specific DNA adduct formation and repair pathways induced by mitomycin C and its analogs.
• Oncology Drug Development: Serves as a key analytical marker in pharmacokinetic and pharmacodynamic studies for novel mitomycin-based chemotherapeutic agents.
• Toxicology Studies: Employed to quantify and characterize DNA damage in cellular and in vitro models, aiding in the assessment of genotoxicity.
• Analytical Method Development: Essential for calibrating and validating advanced analytical techniques such as LC-MS/MS and HPLC for the precise detection of DNA adducts.
• Mechanistic Studies: Facilitates understanding of the structure-activity relationship (SAR) of mitomycin derivatives and their interaction with genetic material.

Basic Information

Product Name	10-Decarbamoylmitomycin C-N(2)-Deoxyguanosine-Adduct
CAS No.	149633-11-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	10-Decarbamoylmitomycin C-deoxyguanosine adduct; Mitomycin C-deoxyguanosine adduct (decarbamoyl); dG-N2-10-Decarbamoylmitomycin C; N2-(10-Decarbamoylmitomycin C)-2'-deoxyguanosine; DNA adduct of decarbamoyl mitomycin C; 10-DMC-dG Adduct
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced spectroscopic and chromatographic methods to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content	Contact for details
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.