Description

2,5-Diamino-4-Hydroxy-6-(2'-Deoxyribosyl)-Formamidopyrimidine is a specialized nucleoside analog and a key intermediate in the synthesis of modified nucleic acids. This compound is critical for research and development in advanced therapeutic areas, particularly in the design of oligonucleotide-based drugs and diagnostic probes. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on antisense therapy, gene silencing, and molecular biology research.

Application

• Oligonucleotide Synthesis: A crucial building block for the solid-phase synthesis of modified DNA strands, enabling the creation of research tools and therapeutic candidates.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific RNA sequences for therapeutic intervention.
• siRNA and miRNA Research: Serves as a modified nucleoside component in small interfering RNA (siRNA) and microRNA (miRNA) constructs to enhance stability and efficacy.
• Diagnostic Probe Manufacturing: Incorporated into labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Biochemical Research: Employed in studies investigating DNA damage, repair mechanisms, and the structural/functional roles of modified bases.
• Pharmaceutical Intermediates: Acts as a high-purity intermediate in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for targeted therapies.

Basic Information

Item	Details
Product Name	2,5-Diamino-4-Hydroxy-6-(2'-Deoxyribosyl)-Formamidopyrimidine
CAS No.	149438-16-4
Molecular Formula	C10H15N5O5
Molecular Weight	285.26 g/mol
Synonyms	2,5-Diamino-4-hydroxy-6-(2-deoxyribosyl)formamidopyrimidine; 2'-Deoxy-2,5-diamino-4-hydroxy-6-formamidopyrimidine; Fapy-dA; FapyAdenine; Formamidopyrimidine derivative; 2'-Deoxyribosylformamidopyrimidine; DNA Lesion Intermediate; 4-Hydroxy-2,5-diamino-6-(2-deoxyribosyl)formamidopyrimidine
EINECS	Contact for details

Quality Control

Our production of 2,5-Diamino-4-Hydroxy-6-(2'-Deoxyribosyl)-Formamidopyrimidine adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards. Our commitment to cGMP principles guarantees batch-to-batch consistency and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.