Description

Tau Protein, Human is a crucial microtubule-associated protein predominantly expressed in neurons, playing a vital role in stabilizing axonal microtubules and regulating intracellular transport. Its significance extends to critical research areas in neuroscience, particularly in understanding neurodegenerative pathologies. This high-purity recombinant protein is essential for researchers and developers in the pharmaceutical, biotechnology, and diagnostic sectors, facilitating studies on tauopathies such as Alzheimer's disease, drug discovery, and the development of novel biomarkers and therapeutic antibodies.

Application

• Biomedical Research: Fundamental studies on microtubule dynamics, axonal transport, and neuronal function.
• Neurodegenerative Disease Modeling: In vitro and in vivo research on tau aggregation, phosphorylation, and the mechanisms underlying tauopathies like Alzheimer's, Frontotemporal Dementia, and Chronic Traumatic Encephalopathy.
• Drug Discovery & Screening: A key target protein for high-throughput screening (HTS) assays to identify potential therapeutic compounds that inhibit pathological tau aggregation or hyperphosphorylation.
• Diagnostic Development: Used as an antigen for the production and calibration of antibodies in ELISA, Western Blot, and immunohistochemistry kits for detecting pathological tau isoforms.
• Biomarker Validation: Serving as a reference standard in mass spectrometry and other analytical methods to quantify tau levels in cerebrospinal fluid (CSF) and blood-based assays.
• Vaccine & Immunotherapy Research: Antigen source for developing active immunization vaccines or passive antibody therapies targeting pathological tau.

Basic Information

Product Name	Tau Protein, Human
CAS No.	149407-41-0
Molecular Formula	Contact for details
Molecular Weight	~45-65 kDa (Isoform-dependent)
Synonyms	Microtubule-Associated Protein Tau; MAPT; Neurofibrillary Tangle Protein; Paired Helical Filament Tau; Tau-4; Tau-F; Recombinant Human Tau Protein; hTau; Tau441; Tau412; Tau Isoforms; Tubulin-Associated Unit Protein
EINECS	Contact for details

Quality Control

Our recombinant Tau Protein, Human is produced under stringent conditions to ensure the highest standards of purity, identity, and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, Western Blot, and mass spectrometry for identity confirmation, and HPLC for purity assessment. We provide full traceability and Certificates of Analysis (COA) detailing purity, concentration, endotoxin levels, and functional activity data upon request, supporting compliance with research and pre-clinical development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized protein at -20°C or below. Upon reconstitution, aliquot and store at ≤ -70°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure it is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Western Blot)	Positive reactivity with anti-Tau antibodies
Protein Content (BCA)	≥ 90% of stated mass
Endotoxin Level (LAL)	< 1.0 EU/μg
Biological Activity	Confirmed by microtubule binding assay (Contact for details)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.