Description

Legumain is a cysteine protease enzyme with significant biological activity, identified by the CAS registry number 149371-18-6. This compound is a critical research tool for studying protein degradation, antigen presentation, and various disease pathways, including cancer and neurodegenerative disorders. It is essential for biopharmaceutical R&D, academic research institutions, and diagnostic kit manufacturers focused on protease activity and biomarker discovery.

Application

• Biomedical Research: Used as a key reagent in enzymatic assays to study legumain's role in tumor progression, inflammation, and immune response.
• Drug Discovery & Development: Serves as a target enzyme for screening and validating novel protease inhibitors in oncology and autoimmune disease research.
• Diagnostic Development: Employed in the development of assays and kits for detecting legumain activity as a potential disease biomarker.
• Protein Biochemistry: Utilized for specific peptide bond cleavage in protein sequencing and structural analysis workflows.
• Cell Biology Studies: Applied in research to investigate intracellular protein processing and lysosomal function.

Basic Information

Product Name	Legumain
CAS No.	149371-18-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LGMN; Asparaginyl Endopeptidase (AEP); Protease, Cysteine 1; PRSC1; δ-Secretase; EC 3.4.22.34
EINECS	Contact for details

Quality Control

Our Legumain is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and stability data. We adhere to relevant guidelines for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Bradford)	Reported per COA
Endotoxin Level (LAL)	< 1.0 EU/μg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.