Description

Hes-1 Protein CAS NO 149348-15-2 is a recombinant protein that plays a critical role in cellular signaling pathways, particularly in the regulation of cell differentiation and proliferation. This high-purity protein is essential for advanced life science research, enabling the study of developmental biology, neurogenesis, and cancer mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on target validation and drug discovery.

Application

• Biomedical Research: Used as a key reagent in studies of Notch signaling pathways, stem cell biology, and tissue development.
• Drug Discovery & Target Validation: Serves as a critical protein target for screening potential therapeutic compounds in oncology and regenerative medicine.
• In Vitro Diagnostics (IVD) Development: Employed as a standard or calibrant in the development of immunoassays and diagnostic kits.
• Cell Culture & Differentiation Studies: Applied in cell-based assays to investigate the effects on progenitor cell fate and differentiation protocols.
• Protein-Protein Interaction Studies: Utilized in pull-down assays, co-immunoprecipitation, and other techniques to map signaling networks.
• Antibody Production & Validation: Acts as a high-quality immunogen for generating specific monoclonal or polyclonal antibodies.

Basic Information

Product Name	Hes-1 Protein
CAS No.	149348-15-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hairy and Enhancer of Split-1 Protein; HES-1; Human HES-1; Recombinant HES-1 Protein; Class B Basic Helix-Loop-Helix Protein 39; bHLHb39; HES1; Hairy/Enhancer-of-split related with YRPW motif 1
EINECS	Contact for details

Quality Control

Our Hes-1 Protein is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and identity confirmation, to ensure consistency and biological activity. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the working environment is dry when handling.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single band at correct molecular weight
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by functional assay (e.g., reporter assay)
Protein Content	Determined by UV absorbance
Solubility	Soluble in appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.