Description

H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(Po3H2)-Gln-Pro-Gly-Glu-Asn-Leu-Oh is a synthetic, phosphorylated peptide sequence of significant interest in biochemical research and pharmaceutical development. This compound is valued for its role in studying signal transduction pathways, particularly those involving tyrosine phosphorylation, a key regulatory mechanism in cellular processes. It serves as a critical research tool for scientists in biotechnology and pharmaceutical R&D, enabling the investigation of kinase activity, protein-protein interactions, and the development of targeted therapeutics.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study the activity and specificity of protein tyrosine kinases and phosphatases.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and validation of novel drugs targeting phosphorylation-dependent diseases, such as cancer and metabolic disorders.
• Diagnostic Reagent Production: Employed in the development of immunoassays and diagnostic kits for detecting phosphorylated proteins and related biomarkers.
• Cell Signaling Studies: Applied in cellular and molecular biology research to elucidate the role of specific phosphorylation sites in signal transduction pathways.
• Antibody Production: Acts as an immunogen for generating phospho-specific antibodies, which are essential tools for proteomics and western blot analysis.

Basic Information

Item	Details
Product Name	H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(Po3H2)-Gln-Pro-Gly-Glu-Asn-Leu-Oh
CAS No.	149299-77-4
Molecular Formula	C66H98N16O33P
Molecular Weight	1635.55 g/mol
Synonyms	Phosphorylated Peptide TSTEPQpYQPGENL; pTyr-containing Peptide; H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO3H2)-Gln-Pro-Gly-Glu-Asn-Leu-OH; TSTEPQpYQPGENL-NH2 (C-terminal acid); Tyrosine Phosphopeptide; c-Src Substrate Peptide (related sequence); Signal Transduction Peptide; Research Peptide 149299-77-4
EINECS	Contact for details

Quality Control

Our H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(Po3H2)-Gln-Pro-Gly-Glu-Asn-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and solvent residues. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, desiccate at -20°C. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.