Description

Microfilarial Sheath Protein Gp22 CAS NO 149255-80-1 is a highly purified, recombinant protein derived from the sheath of parasitic microfilariae. This specialized biochemical is a critical research tool for the study of filarial nematode biology and host-parasite interactions. It is primarily utilized by researchers and developers in the fields of parasitology, veterinary medicine, and pharmaceutical discovery for applications ranging from diagnostic assay development to vaccine research.

Application

• Immunodiagnostic Development: Serves as a key antigen for the development of sensitive and specific ELISA, Western blot, and lateral flow assays for detecting filarial infections.
• Vaccine Research: Investigated as a potential vaccine candidate or target antigen in preclinical studies for lymphatic filariasis and related parasitic diseases.
• Parasite Biology Studies: Used to study the structure, function, and immunogenicity of the microfilarial sheath, aiding in understanding parasite survival and transmission mechanisms.
• Antibody Production: Employed as an immunogen for generating polyclonal or monoclonal antibodies in host animals for research and diagnostic purposes.
• Serological Surveys: Facilitates epidemiological studies by enabling the screening of human and animal populations for exposure to filarial parasites.
• Drug Discovery Screening: Can be used in target-based assays to screen for compounds that interfere with sheath integrity or protein function.

Basic Information

Product Name	Microfilarial Sheath Protein Gp22
CAS No.	149255-80-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gp22 Protein; Microfilarial Sheath Antigen Gp22; Filarial Sheath Protein 22 kDa; Sheath Protein Antigen; Recombinant Gp22; Brugia malayi Sheath Protein (homolog); Diagnostic Antigen Gp22; Parasitic Nematode Antigen
EINECS	Contact for details

Quality Control

Our Microfilarial Sheath Protein Gp22 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, confirmation of identity, and assessment of immunoreactivity. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein aliquots should be stored at -70°C to -80°C and avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Single band at ~22 kDa
Purity (HPLC)	≥ 90%
Protein Content (BCA)	≥ 90% of total weight
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (ELISA)	Reactive with positive control antisera
Solubility	Soluble in PBS or appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.